Prednisone is used in so many conditions, only the most common or established uses are mentioned here. Your doctor about all of your medical conditions and about all other medicines you are using. Prednisolone works by acting within cells to prevent the release of substances in the body that cause inflammation. Corticosteroids produced naturally by the body. You could have unpleasant withdrawal symptoms. Since prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical.